• • Ultrathin CC/DOHA coatings of approximately 150 nm were prepared on TPU via LbL deposition, achieving an adhesion strength of 1 MPa at the TPU-coating interface, addressing the critical bottleneck of coating delamination in clinical catheters.
• • The CC/DOHA16 coating reduced the coefficient of friction by up to 95% compared to uncoated TPU, lowering friction force from 0.5 N to 0.03 N, which is essential for minimizing vascular trauma during interventional procedures.
• • After a 30-minute friction test, the COF of the CC/DOHA16 coating increased only marginally from 0.032 to 0.044, demonstrating excellent lubrication stability under prolonged mechanical stress, a key requirement for long-duration surgeries.
• • The hydrophilic coating reduced vascular intima damage from grade 5 (uncoated) to grade 3, as per the damage evaluation system, confirming its clinical efficacy in reducing friction-induced tissue injury.