Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment

• SDT combines low-intensity ultrasound and sonosensitizers to generate cytotoxic ROS, offering a non-invasive approach with deep tissue penetration for treating deep-seated tumors. • Nanomaterials enhance SDT by improving sonosensitizer delivery, tumor accumulation, and overcoming hypoxia, thereby increasing therapeutic efficacy. • The review highlights recent advances in nanosonosensitizers for both monotherapy and synergistic therapy, particularly for orthotopic tumors that are challenging for conventional treatments. • Despite promising preclinical results, the unclear mechanism and suboptimal efficiency of SDT remain barriers to clinical translation, necessitating further research.