Metal-organic-framework-derived copper-based catalyst for multicomponent C–S coupling reaction

• A CTAB-modified Cu-MOF catalyst was designed to enhance mass transfer in multiphase C–S coupling reactions by increasing substrate adsorption via long alkane chains. • Elemental sulfur was employed as a sustainable, odorless sulfur source, replacing unpleasant and unstable organosulfur reagents, achieving an atom-economical multicomponent reaction. • The study addresses key limitations of Cu-MOF catalysts, including mass-transfer resistance and the instability of organosulfur compounds, advancing the practicality of multiphase catalysis. • The work demonstrates a promising strategy for designing efficient and recyclable copper-based heterogeneous catalysts for C–S bond formation, with potential applications in pharmaceutical and agrochemical synthesis.