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Open AccessDOI: 10.1007/s40820-025-01978-9Original Research

Bright Sparks of Single-Atom and Nano-Islands in Catalysis: Breaking Activity-Stability Trade-Off

Xinyu Liu¹,Suhua Chen¹,Shenglian Luo¹,Bo Li¹,Jiajie Wang¹,Gaoxia Zhang¹,Yuqi Zhu¹,Jianping Zou¹

Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resource Reuse, School of Environmental and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063, People's Republic of China

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Bright Sparks of Single-Atom and Nano-Islands in Catalysis: Breaking Activity-Stability Trade-Off
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Published In
Nano-Micro Letters
Published:January 15, 2026Edition:Vol. 18, Issue 149 • pp. 1-36Citation:Xinyu Liu et al. (2026), Nano-Micro Letters
Impact FactorPeer-Reviewed Core
Source JournalNano-Micro Letters
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Keywords & Index Terms:single-atom catalystsnano-islandsactivity-stability trade-offcatalysisconfinement effectstructure-activity relationshipsynthesis strategiesmechanisms

Key Takeaways & Executive Findings

  • • Single-atom nano-islands architecture enables “moving but not aggregation” of single atoms, fundamentally overcoming the inherent activity-stability trade-off in single-atom catalysts. • Systematic synthesis strategies and multi-scale stabilization mechanisms for single-atom nano-islands are detailed, including one-step and two-step approaches, alongside electronic structure modulation via nano-island interactions. • Single-atom nano-islands demonstrate exceptional performance across diverse catalytic applications, including batteries, clean energy production, chemical synthesis, and environmental catalysis, establishing robust structure-activity relationships. • This review establishes a closed-loop cognitive framework encompassing models, synthesis, high stability mechanisms, high activity essence, and applications, driving a paradigm shift in understanding the multi-dimensional advantages of SANIs.
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Abstract

Single-atom catalysts (SACs) are among the most cutting-edge catalysts in the multiphase catalysis track due to their unique geometrical and electronic properties, the highest atom utilization efficiency, and uniform active sites. SACs have been facing an unresolved problem in practical applications: the opposing contradiction of activity-stability. The successful development of single-atom nano-islands (SANIs) cleverly combines the ultra-high atom utilization efficiency of SACs with the confinement effect and structural stability of nano-island structures, realizing the “moving but not aggregation” of SACs, which fundamentally solves this inherent contradiction. Although research on the precise loading of single atoms on nano-islands continues to advance, existing reviews have not yet established a closed-loop cognitive framework encompassing “models-synthesis-high stability mechanisms-high activity essence-applications.” This work fills this critical gap by systematically integrating the basic conceptual models and cutting-edge synthesis strategies of SANIs, focusing on revealing the underlying mechanisms by which SANIs overcome the stability bottleneck of SACs, elucidating the role of nano-islands and their synergistic mechanisms to clarify the high activity essence, and establishing the structure–activity relationship between atomic confinement effects and macroscopic performance, ultimately achieving breakthrough validation across catalytic systems. This review aims to open new perspectives, drive a paradigm shift in understanding the multi-dimensional advantages of SANIs, and thereby spur breakthrough progress in this frontier field.

1. Introduction

In 2011, Zhang et al. immobilized isolated Pt atoms onto iron oxide (FeOx) (Pt1/FeOx) to show extraordinary catalytic performance for CO oxidation, and proposed the concept of “single-atom catalysts (SACs)” in the field of heterogeneous catalysis for the first time [1]. As soon as the concept of SACs was proposed, it has rapidly developed into one of the most active research frontiers in the field of multiphase catalysis and attracted extensive attention from both academia and industry [2–10]. The “soul idea” of SACs lies in the individual immobilization of catalytically active metal atoms on support materials through precisely designed ligand/ion interactions between neighboring atoms [11]. This atomic-scale dispersion strategy maximizes the utilization efficiency of each metal atoms, significantly improving both catalytic activity and reaction selectivity while optimizing catalytic process efficiency [12–15].

However, SACs face an inherent thermodynamic dilemma, as their extremely ultra-high surface free energy makes them highly susceptible to atomic agglomeration and sintering under high-temperature or reducing operational conditions, leading to structural collapse and a sharp decline in catalytic performance [16–18]. To address the stability issues of SACs, researchers have explored various strategies, including utilizing surface defects [19–22], using N-doped carbon (CN)/oxide supports [23–28], and employing metal-support interactions (MSIs)-based electronic/chemical anchoring strategies to stabilize single atoms (SAs) [29–33], to optimize the coordination environment of SAs and enhance their stability. The activity and stability of SACs are inherently contradictory due to their atomically dispersed structure. High activity stems from the unsaturated coordination environment of isolated metal atoms, while stability requires enhanced MSIs. This fundamental contradiction makes it difficult to achieve both high activity and structural robustness in SACs, thereby becoming the core constraint on their development.

This inherent paradox could be fundamentally resolved if SACs were able to achieve “moving but not aggregating” behavior. With this in mind, the research...

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Cite This Research Paper
Xinyu Liu, Suhua Chen, Shenglian Luo, Bo Li, Jiajie Wang, Gaoxia Zhang, Yuqi Zhu, Jianping Zou (2026). Bright Sparks of Single-Atom and Nano-Islands in Catalysis: Breaking Activity-Stability Trade-Off. Nano-Micro Letters. https://doi.org/10.1007/s40820-025-01978-9
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Frequently Asked Questions

What are single-atom nano-islands (SANIs) and how do they address the activity-stability trade-off in single-atom catalysts?

SANIs combine the ultra-high atom utilization of single-atom catalysts with the confinement effect and structural stability of nano-islands, enabling 'moving but not aggregation' of single atoms, thus fundamentally overcoming the inherent contradiction between activity and stability.

What synthesis strategies are discussed for single-atom nano-islands?

The review details systematic synthesis strategies including one-step and two-step approaches, along with electronic structure modulation via nano-island interactions.

What are the key applications of single-atom nano-islands?

SANIs demonstrate exceptional performance in batteries, clean energy production, chemical synthesis, and environmental catalysis, establishing robust structure-activity relationships.

What is the main contribution of this review?

It establishes a closed-loop cognitive framework encompassing models, synthesis, high stability mechanisms, high activity essence, and applications, filling a critical gap in the field and driving a paradigm shift in understanding SANIs.

What is the significance of the 'moving but not aggregation' concept?

This concept allows single atoms to migrate without aggregating, preserving high activity while maintaining structural stability, thereby resolving the long-standing activity-stability dilemma in single-atom catalysts.

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