• An all-in-one cryogel integrates hemostasis and wound healing for coagulopathic and diabetic patients.
• The cryogel exhibits rapid liquid-triggered volume expansion and synergistic physicochemical hemostatic properties.
• It provides photothermal antibacterial activity, ROS scavenging, oxygen release, and promotes angiogenesis.
• In vivo studies demonstrate superior performance in coagulopathic bleeding and infected diabetic wound healing compared to commercial dressings.