• A novel strategy combining thermal debinding temperature regulation and LaB6 addition effectively mitigates oxygen contamination in MIM Ti6Al4V, achieving a superior strength-ductility synergy.
• The fabricated MIM Ti6Al4V exhibits excellent mechanical properties: UTS of 967 MPa, yield strength of 866 MPa, and elongation of 21.4%, among the best reported for MIM Ti6Al4V.
• The underlying mechanisms include accelerated dislocation slip due to reduced dissolved oxygen, grain refinement, and in situ formation of TiB whiskers and La2O3 particles.
• This work provides a practical pathway for producing high-performance MIM titanium alloys, with potential for industrial scale-up and application in aerospace and biomedical fields.