Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

• Hydrogel-based delivery platforms enhance the therapeutic efficacy of bioactive molecules for bone regeneration by prolonging retention, extending half-lives, and reducing side effects. • Integration of nano-/microscale carriers (e.g., nanoparticles, nanosheets, microspheres) with hydrogels enables controlled and stimuli-responsive release of bioactive molecules. • The review covers applications in cranial and femoral defect repair, periodontal bone regeneration, and bone regeneration under diseased conditions, highlighting versatility. • Challenges and future directions include clinical translation, scalability, and development of multi-functional delivery systems for improved bone repair outcomes.