• Microneedles (MNs) provide a minimally invasive, painless, and targeted drug delivery platform for treating various skin diseases, overcoming limitations of conventional methods.
• Intelligent MNs fabricated from biocompatible materials with specialized properties enhance treatment efficacy and enable controlled release of therapeutics.
• MNs have been applied to a wide range of skin conditions including psoriasis, vitiligo, alopecia, hypertrophic scarring, atopic dermatitis, melanoma, acne, and skin infections.
• Despite progress, challenges such as low drug loading and poor mechanical strength hinder clinical translation, underscoring the need for further research.