• Aerodynamic optimization of high-speed train cross-sections reduces drag by 2.4% in both windless and windy conditions.
• In windy conditions, the aerodynamic lateral force on the leading car is reduced by 37.8%.
• A flat and wide cross-sectional shape lowers aerodynamic drag and lateral loads.
• The Kriging surrogate model combined with genetic algorithm effectively optimizes train body shapes.
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