Integrated Multi-Omics Analysis of Tumor Microenvironment and Immune Infiltration in Hepatocellular Carcinoma: Implications for Prognosis and Immunotherapy

• Distinct tumor microenvironment subtypes in hepatocellular carcinoma are associated with differential prognosis and immune infiltration. • A novel TME-related gene signature accurately predicts overall survival in HCC patients across multiple cohorts. • Integrated multi-omics analysis reveals potential biomarkers for immunotherapy response in HCC. • The study provides a comprehensive resource for understanding TME heterogeneity and its clinical implications in HCC.