• Withdrawal rate is the dominant factor influencing dimensional deformation in investment casting of DD6 turbine blades.
• Shell temperature exhibits a pronounced U-shaped nonlinear effect on deformation, with significant interactions among process parameters.
• The response surface model achieves high predictive accuracy (R²=0.978, RMSE=0.0026 mm) and generalizes well beyond the simulated dataset.
• Optimized process parameters reduce maximum deformation by 5.74% compared to conventional orthogonal design, from 0.2021 mm to 0.1905 mm.
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